酶促仿生可注射水凝胶任务书

 2022-01-21 20:53:39

全文总字数:1707字

1. 毕业设计(论文)的内容和要求

本课题针对现有可注射水凝胶生物相容性差、降解速度不可控等不足,进行结构设计并优化不同水凝胶的性能的具体参数,制备各项性能优异的水凝胶材料。

2. 实验内容和要求

本课题对学生所学知识和技能的要求: 1、对生物基材料进行仿生化修饰; 2、构建酶促可注射水凝胶支架; 3、以合成水凝胶进行性能表征。

3. 参考文献

1.Su T , Zhang D , Tang Z , et al. HRP-mediated polymerization forms tough nanocomposite hydrogels with high biocatalytic performance[J]. Chemical Communications, 2013;49(73):8033.2.Dulong V , Hadrich A , Picton L , et al. Enzymatic cross-linking of carboxy methyl pullulan grafted with ferulic acid[J]. Carbohydrate Polymers, 2016, 151:78-87.3.Kim S H , Lee S H , Lee J E , et al. Tissue adhesive, rapid forming, and sprayable ECM hydrogel via recombinant tyrosinase crosslinking[J]. Biomaterials, 2018, 178:401-412.4.Kang G D , Lee K H , Ki C S , Nahm J H, and Park Y H. Silk fibroin/chitosan conjugate crosslinked by tyrosinase[J]. Macromolecular Research, 2004, 12(5):534-539. 5.Wei Q C, Wang Q G, et al. Printable hybrid hydrogel by dual enzymatic polymerization with superactivity[J]. Chemical Science, 2016, 7. 6.Seo S Y , Sharma V K , Sharma N . Mushroom Tyrosinase: Recent Prospects[J]. Journal of Agricultural and Food Chemistry, 2003, 51(10):2837-2853. 7.Kim S H , Lee S H , Lee J E , et al. Tissue adhesive, rapid forming, and sprayable ECM hydrogel via recombinant tyrosinase crosslinking[J]. Biomaterials, 2018, 178.8.Ghorpade V S , Yadav A V , Dias R J . Citric acid crosslinked, β -cyclodextrin/carboxymethylcellulose hydrogel films for controlled delivery of poorly soluble drugs[J]. Carbohydrate Polymers, 2017, 164:339-348.

4. 毕业设计(论文)计划

2021.1.21前:查阅相关文献,初步了解课题。

2021.2.21前:完成外文翻译、文献综述和开题报告。

2021.5.3前:进行课题设计与实验,处理并分析实验结果。

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