溶剂调控二苯基咪唑衍生物荧光变化的机理探究任务书

 2022-01-19 07:01

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1. 毕业设计(论文)的内容和要求

查阅相关文献及专业书籍了解目前二苯基并咪唑衍生物的发展及其研究现状,了解已有成果以及存在的问题,对论文的研究方向有较深入的认识。

采取合适的实验步骤,适宜的实验条件,合成并纯化目标产物。

培养学生独立思考及动手做实验的能力,养成良好的科研习惯。

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2. 实验内容和要求

(1)合成两个二苯基并咪唑衍生物,学会分析图谱如质谱、核磁及结构鉴定。

(2)检测并分析其光学性质。

实验需要相关原料以及实验和表征设备。

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3. 参考文献

1. Das, K.; Sarkar, N.; Ghosh, A. K.; Majumdar, D.; Nath, D. N.; Bhattacharyya, K., EXCITED-STATE INTRAMOLECULAR PROTON-TRANSFER IN 2-(2'-HYDROXYPHENYL)BENZIMIDAZOLE AND 2-(2'-HYDROXYPHENYL)-BENZOXAZOLE - EFFECT OF ROTAMERISM AND HYDROGEN-BONDING. Journal of Physical Chemistry 1994, 98 (37), 9126-9132.2. Roberts, E. L.; Dey, J.; Warner, I. M., Excited-state intramolecular proton transfer of 2-(2'-hydroxyphenyl)benzimidazole in cyclodextrins and binary solvent mixtures. Journal of Physical Chemistry A 1997, 101 (29), 5296-5301.3. Rios, M. A.; Rios, M. C., Ab initio study of the hydrogen bond and proton transfer in 2-(2 '-hydroxyphenyl)benzothiazole and 2-(2 '-hydroxyphenyl)benzimidazole. Journal of Physical Chemistry A 1998, 102 (9), 1560-1567.4. Fores, M.; Duran, M.; Sola, M.; Orozco, M.; Luque, F. J., Theoretical evaluation of solvent effects on the conformational and tautomeric equilibria of 2-(2 '-hydroxyphenyl)benzimidazole and on its absorption and fluorescence spectra. Journal of Physical Chemistry A 1999, 103 (23), 4525-4532.5. Eseola, A. O.; Li, W.; Sun, W.-H.; Zhang, M.; Xiao, L.; Woods, J. A. O., Luminescent properties of some imidazole and oxazole based heterocycles Synthesis, structure and substituent effects. Dyes and Pigments 2011, 88 (3), 262-273.6. Chipem, F. A. S.; Krishnamoorthy, G., Temperature Effect on Dual Fluorescence of 2-(2 '-Hydroxyphenyl)benzimidazole and Its Nitrogen Substituted Analogues. Journal of Physical Chemistry B 2013, 117 (45), 14079-14088.7. Zhang, Y.; Wang, J. H.; Zheng, W. J.; Chen, T. F.; Tong, Q. X.; Li, D., An ESIPT fluorescent dye based on HBI with high quantum yield and large Stokes shift for selective detection of Cys. Journal of Materials Chemistry B 2014, 2 (26), 4159-4166.8. Rios Vazquez, S.; Perez Lustres, J. L.; Rodriguez-Prieto, F.; Mosquera, M.; Rios Rodriguez, M. C., Excited-State Proton and Charge Transfer in Protonated Amino and Methylated Derivatives of 2-(2 '-Hydroxyphenyl)benzimidazole. Journal of Physical Chemistry B 2015, 119 (6), 2475-2489.9. Omidyan, R.; Iravani, M., Excited State Proton Transfer and Deactivation Mechanism of 2-(4 '-Amino-2 '-hydroxyphenyl)-1H-imidazo 4,5-c pyridine and Its Analogues: A Theoretical Study. Journal of Physical Chemistry A 2016, 120 (7), 1012-1019.10. Prommin, C.; Kanlayakan, N.; Chansen, W.; Salaeh, R.; Kerdpol, K.; Daengngern, R.; Kungwan, N., Theoretical Insights on Solvent Control of Intramolecular and Intermolecular Proton Transfer of 2-(2 '-Hydroxyphenyl)benzimidazole. Journal of Physical Chemistry A 2017, 121 (31), 5773-5784.

4. 毕业设计(论文)计划

2021.01.23-03.10查阅文献,完成翻译和开题报告2021.03.11-04.25熟悉实验技能,制备并纯化目标化合物2021.04.26-05.20对合成的化合物进行分析和表征2021.05.21-06.06撰写毕业论文和答辩PPT

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