1. 毕业设计（论文）的内容和要求
1、毕业论文内容生物表面活性素（surfactin）通常是含有七个氨基酸（GluLeuDLeuValAspDLeuLeu）的七肽与碳的个数为13-15的β-脂肪酸组成。
它是芽孢杆菌产生的一种次级代谢产物，具有可降解，低毒的特点，在医药[1]、食品[2]、生物修复[3]、生物防治[4]等方面具有很大的潜在应用价值[5，6]。
支链氨基酸是surfactin合成的重要前体，它们不仅是surfactin肽环上的重要组成部分，还可以降解为不同链长的支链脂肪酸参与到surfactin脂酰基链的合成[7]。
2. 参考文献
[1] Zhai, S., Q. Shi, and X. Chen, Effect of dietary antimicrobial peptides-surfactin supplementation on parameters of intestinal health indices of genetically improved farmed tilapia (gift, oreochromis niloticus)[J]. Acta Hydrobiologica Sinica, 2016. 40(4): p. 823-829.[2] Zhang, Y., et al., Anti-inflammatory Activity and Mechanism of Surfactin in Lipopolysaccharide-Activated Macrophages[J]. Inflammation, 2015. 38(2): p. 756-764.[3] de Almeida Couto, C.R., et al., Response of the bacterial community in oil-contaminated marine water to the addition of chemical and biological dispersants. Journal Of Environmental Management[J], 2016. 184: p. 473-479.[4] Jasim, B., J. Mathew, and E.K. Radhakrishnan, Identification of a novel endophytic Bacillus sp from Capsicum annuum with highly efficient and broad spectrum plant probiotic effect[J]. Journal Of Applied Microbiology, 2016. 121(4): p. 1079-1094.[5] 翟少伟, 李剑,史庆超, 抗菌脂肽Surfactin的抗菌活性及应用[J]. 动物营养学报, 2015(05): p. 1333-1340.[6] 任鹏举, 枯草芽孢杆菌OKB105产生的surfactin防治烟草花叶病毒病及其机理研究[J]. 中国生物防治学报, 2014(02): p. 216-221.[7] Hu F, Liu Y, Li S. Rational strain improvement for surfactin production: enhancing the yield and generating novel structures[J]. Microbial cell factories, 2019, 18(1): 42.[8] Liu J F, Yang J, Yang S Z, et al. Effects of different amino acids in culture media on surfactin variants produced by Bacillus subtilis TD7[J]. Applied biochemistry and biotechnology, 2012, 166(8): 2091-2100.[9] Zhou D, Hu F, Lin J, et al. Genome and transcriptome analysis of Bacillus velezensisBS‐37, an efficient surfactin producer from glycerol, in response to d‐/l‐leucine[J]. MicrobiologyOpen, 2019: e794.[10]Coutte F, Niehren J, Dhali D, John M, Versari C, Jacques P. Modeling leucine's metabolic pathway and knockout prediction improving the production of surfactin, a biosurfactant from Bacillus subtilis. Biotechnology Journal, 2015, 10(8): 1216-1234.
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