虫草素治疗糖尿病诱发的勃起功能障碍的初步药效研究任务书

 2021-10-21 05:10

1. 毕业设计(论文)的内容和要求

1.文献查阅掌握文献查阅的一般方法,学会使用计算机在中国期刊网,维普数据库,超星数字图书馆,Elsevier、NCBI电子期刊,Springer Link全文电子期刊,Web of Science等检索资源上查阅关于勃起功能障碍的相关文献。

2.文献阅读及综述阅读与虫草素、糖尿病、勃起功能障碍等相关的外文及中文文献,了解国内外的研究动态,撰写文献综述。

3.明确实验任务,拟定实验方案根据所查阅文献的内容,确定实验内容及方案,拟定科学可行的研究计划。

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2. 参考文献

[1] Li WJ, Xu M, Gu M, et al. Losartan preserves erectile function by suppression of apoptosis and fibrosis of corpus cavernosum and corporal veno-occlusive dysfunction in diabetic rats. Cell. Physiol Biochem. 2017,42(1): 333-345.[2] Mulhall JP, Mller A, Donohue JF, et al. FK506 and erectile function preservation in the cavernous nerve injury model:optimal dosing and timing. J Sex Med. 2008,5(6): 1334-1344.[3]Bivalacqua TJ, Kendirci M, Champion HC, Hellstrom WJG,Andersson KE, Hedlund P. Dysregulation of cGMP-dependent protein kinase 1 (PKG‐1) impairs erectile function in diabetic rats: influence of in vivo gene therapy of PKG1alpha. BJU Int.2007,99(6): 1488-1494.[4]Li H, He WY, Lin F, Gou X. Panax notoginseng saponins improve erectile function through attenuation of oxidative stress, restoration of Akt activity, and protection of endothelial and smooth muscle cells in diabetic rats with erectile dysfunction. Urol Int. 2014,93(1): 92-99.[5] Burgers JK, Nelson RJ, Quinlan DM, Walsh PC. Nerve growth factor, nerve grafts, and amniotic membrane grafts restore erectile function in rats. J Urol. 1991,146(2): 463-468.[6] Won KJ, Lee SC, Lee CK, Lee HM, Lee SH, Fang Z, et al. Cordycepin attenuates neointimal formation by inhibiting reactive oxygen species-mediated responses in vascular smooth muscle cells in rats. J Pharmacol Sci. 2009,109: 403-412.[7] Li Y.,Li R.,Zhu S.,Zhou R., Wang L.,Du J.,Wang Y.,Zhou, B.,Mai, L. Cordycepin induces apoptosis and autophagy in human neuroblastoma SK-N-SH and BE (2)-M17 cells. Oncol. Lett. 2015, 9: 2541-2547.[8]Kim HG, hrestha B, Lim SY et al. Cordycepin inhibits lipopolysaccharide-inducedinflammation by the suppression of NF-kB through Akt and p38 inhibition in Raw264.7 macrophage cells. Eur J Pharmacol. 2006,545: 192-9.[9]Guo P,Kai Q,Gao J,Lian ZQ,Wu CM,Wu CA,etal. Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase. J PharmacolSci. 2010,113: 395-403.[10]Wu C,Guo Y,Su Y,Zhang X,Luan H,Zhang X,etal.Cordycepin activates AMP-activatedproteinkinase(AMPK) via interaction with the gamma1subunit. J CellMolMed. 2014,18: 293-304.[11] Ma L,Zhang S,Du M.Cordycepinfrom Cordycepsmilitaris prevents hyperglycemia inalloxan-induceddiabeticmice. Nutr Res. 2015,35: 431-9.[12] Li X,Zhou Y,Zhang X,Cao X,Wu C,Guo P.Cordycepin stimulates autophagy in macrophages and prevents atherosclerotic plaque formation in ApoE/mice. Oncotarget. 2017,8: 94726-37.[13]Zhang P,Huang C,Fu C,Tian Y,Hu Y,Wang B,etal.Cordycepin (3'-deoxyadenosine) suppressed HMGA2,Twist1 and ZEB1-dependent melanoma invasion andmetastasis by targetingmiR-33b.Oncotarget.2015,6: 9834-53.[14] Wong YY,Moon A,Duffin R,Barthet-Barateig A,Meijer HA,Clemens MJ,etal.Cordycep ininhibits protein synthesis and cell adhesion through effects on signal transduction. J BiolChem.2010,285: 2610-21.

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