4-溴-1,2-二(溴甲基)苯的合成工艺研究任务书

 2021-10-21 05:10

1. 毕业设计(论文)的内容和要求

1、毕业论文内容溴是元素周期表中最重要的元素之一。

但由于元素溴具有危险性和强刺激性,因此存在一定的处理风险。

当人体吸入溴蒸气时,无论吸入的浓度高低都会严重损害呼吸系统,因此人们需要特别的预防措施来使用和处理溴。

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2. 参考文献

[1] Herrmann, H.; Majdik, Z.; Ervens, B.; Weise, D. Halogen Production from Aqueous Tropospheric Particles[J]. Chemosphere., 2003, 52, 485502.[2] Rasmussen, R. A.; Khalil, M. A. K.; Dalluge, R. W.; Penkett, S. A.; Jones, B. A Somewhat Forgotten Physicist[J]. Science., 1982, 215, 655 656.[3] Butler, A.; Sandy, M. Mechanistic Considerations of Halogenating Enzymes[J]. Nature., 2009, 460, 848.[4] ) Vaillancourt, F. H.; Yeh, E.; Vosburg, D. A.; Garneau-Tsodikova, S.; Walsh, C. T. Natures Inventory of Halogenation Catalysts: Oxidative Strategies Predominate[J]. Chem. Rev., 2006, 106, 33643378.[5] Rogers, J. V.; Price, J. A.; Wendling, M. Q. S.; Perry, M. R.; Reid, F. M.; Kiser, R. C.; Graham, J. S. J. Biochem. An Assessment of Transcriptional Changes in Porcine Skin Exposed to Bromine Vapor[J]. Biochem. Mol. Toxicol ., 2011, 25, 252262.[6] Varma, P. S.; Narayan, B. Q. Halogenation. III. Bromination[J]. Indian Chem. Soc., 1927, 4, 283289.[7] Jakes, M. Hydrogenation of Ar-1,3-dibromo-2-tetralol by Means of Bromine[J]. Collect. Czech. Chem. Commun., 1929, 1, 245256[8] Wheeler, A. S.; Ergle, D. R. Naphthol Studies. i. the Bromination of 1,5-dihydroxynaphthalene[J]. Am. Chem. Soc., 1930, 52, 48724880.[9] Heller, G.; Dietrich, W.; Hemmer, T.; Katzel, H.; Rottsahl, E.; Zambalos, P. G. Action of Bromine on Phenols[J]. Prakt. Chem., 1931, 129, 211256.[10] Brink, M. Bromination of Some Phenolic Alcohols. Acta Univ. Lund., Sect. II 1965, 21, 13.[11] Pearson, D. E.; Wysong, R. D.; Breder, C. V. OrthoBromination of Phenol[J]. Org. Chem., 1967, 32, 23582360.[12] Vidyasagar, A.; Nalawala, K. J.; Varshney, A. K. A Novel TwoStep Synthesis of 3,5-Dibromo-4-hydroxybenzonitrile[J]. Indian J. Chem., 1993, 32B, 872873.[13] Yang, S.; Huang, W.; Li, D.; Song, Q.; Hao, J.; Ding, R.; Xu, Y. Method for preparing 3,5-dibromo-4-hydroxybenzaldehyde. Faming Zhuanli Shenqing Gongkai Shuomingshu CN 101250097 A 20080827, 2008.[14] Chumachenko, T. N.; Dorofeev, V. T. Preparation of 3,5- Dibromo-4-hydroxybenzoic Acid[J]. Vopr. Khim. Khim. Tekhnol., 1988, 86, 7374.[15] Wohl, A. Bromination of Unsaturated Compounds with NBromoacetamide, A Contribution to the Study of the Course of Chemical Processes[J]. Ber. Dtsch. Chem. Ges. B., 1919, 52B, 5163.[16] ) Koval, I. V. N-Halo Reagents. N-Halosuccinimides in Organic Synthesis and in Chemistry of Natural Compounds[J]. Russ. J. Org. Chem., 2002, 38, 301337.[17] ) Ziegler, K.; Spath, A.; Schaaf, E.; Schumann, W.; Winkelmann, E. Halogenation of Unsaturated Substances in The Allyl Position[J]. Ann. Chem.,1942, 551, 80119.[18] Bloomfield, G. F. Rubber, Polyisoprenes, and Allied Compounds. Part VI. The Mechanism of Halogen-Substitution Reactions, and the Additive Halogenation of Rubber and of Dihydromyrcene[J]. Chem. Soc., 1944, 114120.[19] Adam, J.; Gosselain, P. A.; Goldfinger, P. Laws of Addition and Substitution in Atomic Reactions of Halogens[J]. Nature., 1953, 171, 704705.[20] Misra, G. S.; Shukla, J. S. J. Side-Chain Bromination of Some Aromatic Compounds with N-Bromosuccinimide[J]. Indian Chem., Soc., 1951, 28, 275279.[21] Qvist, W. Several Brominations of Aromatic Hydrocarbons with N-Bromosuccinimide[J]. Acta Acad. Abo., Math. Phys., 1952, 18, 14.[22] Lee, H. S.; Spraggon, G.; Schultz, P. G.; Wang, F. Genetic Incorporation of A Metal-Ion Chelating Amino Acid into Proteins as A Biophysical Probe[J]. Am. Chem. Soc., 2009, 131, 24812483.[23] Horvath, A.; Nussbaumer, P.; Wolff, B.; Billich, A. 2-(1- Adamantyl)-4-(Thio)Chromenone-6-Carboxylic Acids: Potent Reversible Inhibitors of Human Steroid Sulfatase[J]. Med. Chem., 2004, 47, 42684276Croce, T. A.; Hamilton, S. K.; Chen, M. L.; Muchalski, H.; Harth, E. Alternative o-Quinodimethane Cross-Linking Precursors for Intramolecular Chain Collapse Nanoparticles[J]. Macromolecules., 2007, 40, 6028-6031.

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