虎杖苷抑制对乙酰氨基酚诱导的小鼠肝损伤研究任务书

 2021-10-21 05:10
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1. 毕业设计(论文)的内容和要求

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对C57BL/6小鼠腹腔注射对乙酰氨基酚,建立肝损伤模型,对模型C57BL/6小鼠灌胃给药虎杖苷进行治疗,观察模型C57BL/6小鼠活动状态的变化,考察体内效果。

摘除模型C57BL/6小鼠肝器官进行H 对C57BL/6小鼠腹腔注射对乙酰氨基酚,建立肝损伤模型;2) 对模型C57BL/6小鼠灌胃给药虎杖苷进行治疗,观察模型C57BL/6小鼠活动状态的变化,考察体内效果;3) 摘除模型C57BL/6小鼠肝器官进行H 44: 1299-303.2 Nourjah P, Ahmad SR, Karwoski C, Willy M. Estimates of acetaminophen (paracetamol)-associated overdoses in the United States. Pharmacoepidem Dr S 2006; 15: 398-405.3 Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005; 42: 1364-72.4 Klotz U. Paracetamol (Acetaminophen) - a Popular and Widely Used Nonopioid Analgesic. Arzneimittelforsch 2012; 62: 355-9.5 Bateman DN, Dear JW, Thanacoody HKR, Thomas SHL, Eddleston M, Sandilands EA, et al. Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. Lancet 2014; 383: 697-704.6 Liu X, Wang X, Tong J. Radon-induced alterations in p53-mediated energy metabolism of malignantly transformed human bronchial epithelial cells. Journal of toxicology and environmental health. Part A 2016; 79: 436-41.7 Potter DW, Hinson JA. Reactions of N-Acetyl-P-Benzoquinone Imine with Reduced Glutathione, Acetaminophen, and Nadph. Mol Pharmacol 1986; 30: 33-41.8 Jaeschke H, Gores GJ, Cederbaum AI, Hinson JA, Pessayre D, Lemasters JJ. Forum - Mechanisms of hepatotoxicity. Toxicol Sci 2002; 65: 166-76.9 Xie YC, McGill MR, Dorko K, Kumer SC, Schmitt TM, Forster J, et al. Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. Toxicol Appl Pharm 2014; 279: 266-74.10 Larson AM. Acetaminophen hepatotoxicity. Clin Liver Dis 2007; 11: 525-48, vi.11 Regev-Shoshani G, Shoseyov O, Bilkis I, Kerem Z. Glycosylation of resveratrol protects it from enzymic oxidation. Biochem J 2003; 374: 157-63.12 Zhao XJ, Yu HW, Yang YZ, Wu WY, Chen TY, Jia KK, et al. Corrigendum to "Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway" [Redox Biol. 18 (2018) 124-137]. Redox biology 2019: 101101.

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