1. 毕业设计（论文）的内容和要求
肝脏是人体新陈代谢的主要器官，具有解毒、代谢、免疫等功能，肝损伤会影响肝脏的功能。
肝损伤是一类严重的健康问题，它可能由许多病因所引起，例如：病毒、药物、酒精、自身免疫失调等[1,2]。
据文献报道，药物诱导是造成肝损伤的主要原因，并且很可能引起急性肝衰竭[3]。
2. 参考文献
[1]M.A. Heneghan, A.D. Yeoman, S. Verma, A.D. Smith, M.S. Longhi, Autoimmune hepatitis, Lancet 382 (9902) (2013) 14331444.[2] C. Wang, Y. Xia, Y. Zheng, W. Dai, F. Wang, K. Chen, J. Li, S. Li, R. Zhu, J. Yang, Q. Yin, H. Zhang, J. Wang, J. Lu, Y. Zhou, C. Guo, Protective effects of N-acetylcysteine in concanavalin A-induced hepatitis in mice, Mediators Inflamm. 2015(2015) 189785. [3]Watkins PB, Merz M, Avigan MI, Kaplowitz N, Regev A, Senior JR. The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future. Drug Saf 2014;37(Suppl 1):S1-S7.[4]Si Qin, Chenghao Lv, Qingshan Wang, Zhibing Zheng, Xi Sun, Minyi Tang, Fangming Deng, Extraction, identification, and antioxidant property evaluation of limonin from pummelo seeds, Animal Nutrition. 4 (2018) 281e287.[5]Tian, Q.; Miller, E. G.; Ahmad, H.; Tang, L.; Patil, B. S. Nutr. Cancer 2001, 40, 180.[6]K. Langeswaran, S.G. Kumar, S. Perumal, R. Revathy, M.P. Balasubramaniam, Limonin-A citrus limonoid, establish anticancer potential by stabilizing lipid peroxidation and antioxidant status against N-nitrosodiethylamine induced experimental hepatocellular carcinoma, Biomed. Prev. Nutr. 3 (2013) 165171.[7]El-Readi, M. Z., Hamdan, D., Farrag, N., El-Shazly, A., Wink, M. (2010). Inhibition of Pglycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines. European Journal of Pharmacology, 626, 139145.[8]Jayaprakasha, G. K., Mandadi, K. K., Poulose, S. M., Jadegoud, Y., Nagana-Gowda, G. A., Patil, B. S. (2008). Novel triterpenoid from Citrus aurantium L. possesses chemopreventive properties against human colon cancer cells. Bioorganic Medicinal Chemistry, 16(11), 59395951.[9]Murthy, K. N. C., Jayaprakasha, G. K., Kumar, V., Rathore, K. S., Patil, B. S. (2011). Citrus limonin and its glucoside inhibit colon adenocarcinoma cell proliferation through apoptosis. Journal of Agriculture and Food Chemistry, 59, 23142323.
