1. 毕业设计（论文）的内容和要求
肠道菌群组成及调节对维持肠道内健康稳定状态具有重要意义。
由于斑马鱼具有与人类高度保守的先天免疫系统的构成（Toll样受体，中性粒细胞和巨噬细胞），近年来，斑马鱼被用于大量的肠免疫研究。
研究表明，定植在斑马鱼肠道内的菌群会利用各种方式对斑马鱼肠道的免疫进行调节；特定的菌种会触发特定的免疫调节，即使此菌种在总菌群内只占有少数比例，依然可以发挥其功效。
2. 参考文献
[1]Johansson, M. E. V. et al. Normalization of host intestinal mucus layers requires long-term microbial colonization. Cell. Host Microbe 18, 582592 (2015).[2]Wen, L. et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 455, 11091113 (2008).[3]Backhed, F. et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell. Host Microbe 17, 690703 (2015)[4]Rolig AS, Mittge EK, Ganz J, Troll JV, Melancon E, Wiles TJ, et al. (2017) The enteric nervous system promotes intestinal health by constraining microbiota composition. PLoS Biol 15(2): e2000689. doi:10.1371/journal. pbio.2000689[5]Annah S Rolig,Raghuveer Parthasarathy, Adam R Burns. art al. Individual members of the microbiota disproportionately modulate host innate immune responses. Cell Host Microbe. 2015 November 11; 18(5): 613620
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