1. 毕业设计（论文）的内容和要求
1．文献查阅 掌握文献查阅的一般方法，学会使用计算机在中国期刊网，维普数据库，超星数字图书馆，Elsevier、NCBI电子期刊，Springer Link全文电子期刊，Web of Science等检索资源上查阅关于内质网应激的相关文献。
2．文献阅读及综述 阅读与桃叶珊瑚苷、睾丸损伤、内质网应激等相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。
3．明确实验任务，拟定实验方案 根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。
2. 参考文献
[1] Jung E, Park SB, Jung WK, Kim HR, Kim J. Aucubin, An Active Ingredient in Aucuba japonica, Prevents N-methyl-N-nitrosourea-induced Retinal Degeneration in Mice. Molecules. 2019. 24(24).[2] Song M, Han M, Kim KY. Effect of aucubin on neural precursor cell survival during neuronal differentiation. Int J Neurosci. 2018. 128(10): 899-905.[3] Jung E, Park SB, Jung WK, Kim HR, Kim J. Antiglycation Activity of Aucubin In Vitro and in Exogenous Methylglyoxal Injected Rats. Molecules. 2019. 24(20).[4] Wang BW, Jiang Y, Yao ZL, Chen PS, Yu B, Wang SN. Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model. Drug Des Devel Ther. 2019. 13: 3529-3538.[5] Duan M, Yuan Y, Liu C, Cai Z, Xie Q, Hu T, et al. Indigo Fruits Ingredient, Aucubin, Protects against LPS-Induced Cardiac Dysfunction in Mice. J Pharmacol Exp Ther. 2019. 371(2): 348-359.[6] Ma B, Zhang J, Zhu Z, Bao X, Zhang M, Ren C, et al. Aucubin, a natural iridoid glucoside, attenuates oxidative stress-induced testis injury by inhibiting JNK and CHOP activation via Nrf2 up-regulation. Phytomedicine. 2019. 64: 153057.[7] Shen B, Zhao C, Wang Y, Peng Y, Cheng J, Li Z, et al. Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/HO-1 and AMPK signalling pathways. J Cell Mol Med. 2019. 23(6): 4063-4075.[8] Pan B, Zhou Y, Kong G, Li P, Guo Q, Guan C. [Aucubin alleviates lipopolysaccharide-induced acute lung injury in mice]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2019. 44(2): 128-133.[9] Huang TL, Yang SH, Chen YR, Liao JY, Tang Y, Yang KC. The therapeutic effect of aucubin-supplemented hyaluronic acid on interleukin-1beta-stimulated human articular chondrocytes. Phytomedicine. 2019. 53: 1-8.[10] Chen S, Zeng X, Zong W, Wang X, Chen L, Zhou L, et al. Aucubin Alleviates Seizures Activity in Li-Pilocarpine-Induced Epileptic Mice: Involvement of Inhibition of Neuroinflammation and Regulation of Neurotransmission. Neurochem Res. 2019. 44(2): 472-484.[11] Yang S, Li L, Zhu L, Zhang C, Li Z, Guo Y, et al. Aucubin inhibits IL-1β- or TNF-α-induced extracellular matrix degradation in nucleus pulposus cell through blocking the miR-140-5p/CREB1 axis. J Cell Physiol. 2019. 234(8): 13639-13648.[12] Kang WS, Jung E, Kim J. Aucuba japonica Extract and Aucubin Prevent Desiccating Stress-Induced Corneal Epithelial Cell Injury and Improve Tear Secretion in a Mouse Model of Dry Eye Disease. Molecules. 2018. 23(10).[13] Yang Z, Wu QQ, Xiao Y, Duan MX, Liu C, Yuan Y, et al. Aucubin Protects against Myocardial Infarction-Induced Cardiac Remodeling via nNOS/NO-Regulated Oxidative Stress. Oxid Med Cell Longev. 2018. 2018: 4327901.[14] Zhu Z, Xie Q, Huang Y, Zhang S, Chen Y. Aucubin suppresses Titanium particlesmediated apoptosis of MC3T3E1 cells and facilitates osteogenesis by affecting the BMP2/Smads/RunX2 signaling pathway. Mol Med Rep. 2018. 18(3): 2561-2570.[15] Zhu YL, Sun MF, Jia XB, Zhang PH, Xu YD, Zhou ZL, et al. Aucubin alleviates glial cell activation and preserves dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian mice. Neuroreport. 2018. 29(13): 1075-1083.[16] Qiu YL, Cheng XN, Bai F, Fang LY, Hu HZ, Sun DQ. Aucubin protects against lipopolysaccharide-induced acute pulmonary injury through regulating Nrf2 and AMPK pathways. Biomed Pharmacother. 2018. 106: 192-199.
以上是毕业论文任务书，课题毕业论文、开题报告、外文翻译、程序设计、图纸设计等资料可联系客服协助查找。
