1. 毕业设计（论文）的内容和要求
多通路分子探针是指对于同一待分析物，探针本身可以通过多种信号给予响应，从而对待分析物进行定性定量分析。
常见的识别信号为色度、荧光、电化学、磁性等，由于从多个角度对待分析物进行分析，可以得到多个检测结果，通过比对分析，可以增加待分析物检测结果的准确性。
所以对于干扰因素较多的体系或待分析物浓度不稳定体系的，选用多通路分子探针进行测定是一种优化的方法。
2. 参考文献
[1] 焦晨旭. 荧光光化学传感器 [M]. 太原：山西科技出版社，2008. [2] Joseph, R. L. Principles of fluorescence spectroscopy [M]. 影印版. 北京：科学出版社，2008. [3] 许金钩，王尊本. 荧光分析法 [M]. 第三版. 北京：科学出版社，2006. [4] 刘爱平. 细胞生物学荧光技术原理和应用 [M]. 第二版. 合肥：中国科学技术大学出版社，2012. [5] 王立强. 生物技术中的荧光分析 [M]. 北京：机械工业出版社，2010. [6] 鞠熀先，约瑟夫王. 电化学与生物传感器:：原理、设计及其在生物医学中的应用 [M]. 北京：化学工业出版社，2009. [7] Carl, H. H., Andrew, H., Wolf, V. Electrochemistry [M]. 北京：化学工业出版社，2010. [8] Kumar, M., Kumar, N., Bhalla, V., et al. Naphthalimide Appended Rhodamine Derivative: Through Bond Energy Transfer for Sensing of Hg2 Ions [J]. Org. Lett., 2011, 13, 1422-1425. [9] Zhou, Z. G., Yu, M. X., Yang, H., et al. FRET-based sensor for imaging chromium(III) in living cells [J]. Chem. Commun., 2008, 3387-3389. [10] Xu, Z. C., Qian, X. H., Cui, J. N. Colorimetric and Ratiometric Fluorescent Chemosensor with a Large Red-Shift in Emission: Cu(II)-Only Sensing by Deprotonation of Secondary Amines as Receptor Conjugated to Naphthalimide Fluorophore [J]. Org. Lett. 2005, 7, 3029-3032. [11] Liu, Z. P., Zhang, C. L., Wang, X. Q., et al. Design and Synthesis of a Ratiometric Fluorescent Chemosensor for Cu(II) with a Fluorophore Hybridization Approach [J]. Org. Lett. 2012, 14, 4378-4381. [12] Xu, Z. C., Xiao, Y., Qian, X. H., et al. Ratiometric and Selective Fluorescent Sensor for CuII Based on Internal Charge Transfer (ICT) [J]. Org. Lett. 2005, 7, 889-892. [13] Yang, H., Zhou, Z. G., Huang, K. W., et al. Multisignaling Optical-Electrochemical Sensor for Hg2 Based on a Rhodamine Derivative with a Ferrocene Unit [J]. Org. Lett., 2007, 9, 4729-4732. [14] Huang, K. W., Yang, H., Zhou, Z. G., et al. Multisignal Chemosensor for Cr3 and Its Application in Bioimaging [J]. Org. Lett., 2008, 10, 2557-2560. [15] Wu, D. Y., Huang, W., Lin, Z. H., et al. Highly Sensitive Multiresponsive Chemosensor for Selective Detection of Hg2 in Natural Water and Different Monitoring Environments [J]. Inorg. Chem., 2008, 47, 7190-7201. [16] Romero, T., Caballero, A., Espinosa, A., et al. A multiresponsive two-arm ferrocene-based chemosensor molecule for selective detection of mercury [J]. Dalton Trans., 2009, 2121-2129. [17] Shi, L., Song, W., Li, Y., et al. A multi-channel sensor based on 8-hydroxyquinoline ferrocenoate for probing Hg(II) ion [J]. Talanta, 2011, 84, 900-904. [18] Pandey, R., Gupta, R. K., Shahid, M., et al. Synthesis and Characterization of Electroactive Ferrocene Derivatives: Ferrocenylimidazoquinazoline as a Multichannel Chemosensor Selectively for Hg2 and Pb2 Ions in an Aqueous Environment [J]. Inorg. Chem., 2012, 51, 298-311. [19] Alfonso, M., Garca, J. C., E`spinosa, A., et al. Highly selective mercury( II ) cations detection in mixed aqueous media by a ferrocene-based fl uorescent receptor [J]. Dalton Trans., 2012, 41, 4437-4444. [20] Otn, F., Trraga, A., Velasco, M. D., et al. A new fluoride selective electrochemical and fluorescent chemosensor based on a ferrocene-naphthalene dyad [J]. Chem. Commun., 2004, 1658-1659. [21] Zapata, F., Caballero, A., T`arraga, A., et al. Ferrocene-Substituted Nitrogen-Rich Ring Systems as Multichannel Molecular Chemosensors for Anions in Aqueous Environment [J]. J. Org. Chem., 2010, 75, 162-169. [22] Alfonso, M., T`arraga, A., Molina, P. A Bisferrocene-Benzobisimidazole Triad as a Multichannel Ditopic Receptor for Selective Sensing of Hydrogen Sulfate and Mercury Ions [J]. Org. Lett., 2011, 13, 6432-6435. [23] Alfonso, M., Espinosa, A., Ta′rraga, A., et al. Multichannel HSO4- recognition promoted by a bound cation within a ferrocene-based ion pair receptor [J]. Chem. Commun., 2012, 48, 6848-6850. [24] Li, X. L., Lin, Y. J., Wang, Q. Q., et al. The novel anti-tumor agents of 4-triazol-1,8-naphthalim ides: Synthesis, cytotoxicity, DNA intercalation and photocleavage [J]. Eur. J. Med. Chem., 2011, 46, 1274-1279.
