精氨酸脱亚胺酶纳米反应器的构建与评价任务书

 2021-08-22 23:57:45

1. 毕业设计(论文)主要内容:

(1)光交联羧甲基壳聚糖钠盐(Az-NaCMCS)的制备;

(2)壳交联前Az-NaCMCS纳米囊的制备;

(3)Az-NaCMCS纳米囊泡的表征。

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2. 毕业设计(论文)主要任务及要求

1、查阅不少于30篇的相关资料,其中英文文献不少于5篇,完成开题报告;

2、光交联羧甲基壳聚糖钠盐(Az-NaCMCS)的制备;

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3. 毕业设计(论文)完成任务的计划与安排

第一~三周:查阅文献,调研,完成开题报告;

第四~五周:了解课题背景,熟悉课题内容;

第六周:准备实验材料;

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4. 主要参考文献

[1]Chen, X. G., Park, H. J., 2003. Chemical characteristics of O-carboxymethyl chitosans related to the preparation conditions. Carbohydr. Polym. 53, 355–359.[2]Ensor, C.M., Holtsberg, F.W., Bomalaski, J.S., Clark, M.A., 2002. PEGylated argininedeiminase (ADI-SS PEG 20,000 MW) inhibits human melanomas and hepatocellularcarcinomas in vitro and in vivo. Cancer. Res. 62, 5443–5450.[3]Feun, L.G., Kuo, M.T., Savaraj.N, 2015. Arginine deprivation in cancer therapy. Curr. Opin. Clin.Nutr. Metab. Care. 18(1):78-82.[4]Feun, L., You, M., Wu, C.J., Kuo, M.T., Wangpaichitr. M., Spector. S., Savaraj. N., 2008. Arginine deprivation as a targeted therapy for cancer. Curr. Pharm. Des. 14(11):1049-57.[5]Germain, M., Grube, S., Carriere, V., Richard-Foy, H., Winterhalter, M., Fournier, N., 2006. Composite Nanocapsules: Lipid Vesicles Covered with Several Layers of Crosslinked Polyelectrolytes. Adv. Mater. 18 21: 2868-2871.[6]Grfe, D., Gaitzsch, J., Appelhans, D., Voit., B., 2014. Cross-linked polymersomes as nanoreactors for controlled and stabilized single and cascade enzymatic reactions. Nanoscale. 6, 10752-61

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