1. 毕业设计（论文）的内容和要求
1、毕业论文内容Serrawettins是由粘质沙雷氏菌所产的一种脂肽类生物表面活性剂[1]，具有典型的两亲性分子结构亲水端由氨基酸或肽构成，亲油端由β-羟基脂肪酸构成[2]。
根据结构差异， serrawettins可分为serrawettin W1、serrawettin W2和serrawettin W3[3-5]；又因脂肪酸链长或氨基酸残基的差异，serrawettins存在多种同系物组分（congeners）或异构体（isoforms）。
Serrawettins的产生和培养温度息息相关，在30℃培养时会合成serrawettin；在37℃培养时则不合成[6]。
2. 参考文献
[1] Matsuyama T, Sogawa M, Nakagawa Y. Fractal spreading growth of Serratia marcescens which produces surface active exolipids[J]. FEMS Microbiol Lett, 1989, 61(3): 243-246.[2] Matsuyama T, Kaneda K, Nakagawa Y, et al. A novel extracellular cyclic lipopeptide which promotes flagellum-dependent and-independent spreading growth of Serratia marcescens[J]. J Bacteriol, 1992, 174(6): 1769-1776.[3] Matsuyama T, Tanikawa T, Nakagawa Y. Serrawettins and other surfactants produced by Serratia [M]//SOBERn-Chvez G. Biosurfactants: microbiology monographs.Berlin:Springer, 2011.[4] Su C, Xiang Z, Liu Y, et al. Analysis of the genomic sequences and metabolites of Serratia surfactantfaciens sp. nov. YD25T that simultaneously produces prodigiosin and serrawettin W2[J]. BMC Genom, 2016, 17(1):865.[5] Matsuyama T, Murakami T, Fujita M, et al. Extracellular vesicle formation and biosurfactant Production by Serratia marcescens[J]. Microbiology, 1986, 132(4):865-875.[6] Eckelmann D, Spiteller M, Kusari S. Spatial-temporal profiling of prodiginines and serratamolides produced by endophytic Serratia marcescens harbored in Maytenus serrata[J]. Sci Rep, 2018, 8(1): 5283.[7] Dwivedi D, Jansen R, Molinari G, et al. Antimycobacterial serratamolides and diacyl peptoglucosamine derivatives from Serratia sp[J]. J Nat Prod, 2008, 71(4): 637-641.[8] Zhu L, Pang C, Chen L, et al. Antibacterial activity of a novel depsipeptide and prodigiosine of Serratia marcescens S823[J]. Nat Prod Chem Res, 2018, 6: 312.[9] Motley J L , Stamps B W , Mitchell C A , et al. Opportunistic sampling of roadkill as an entry point to accessing natural products assembled by bacteria associated with non-anthropoidal mammalian microbiomes[J]. J Nat Prod, 2016, 80(3):598-608.[10] Clements T, Ndlovu T, Khan S, et al. Biosurfactants produced by Serratia species: classification, biosynthesis, production and application[J]. Appl Microbiol Biotechnol, 2019, 103(2): 589-602.
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