全文总字数：3550字
1. 毕业设计（论文）的内容和要求
本课题为了研究三亚甲基碳酸脂与外消旋丙交酯共聚物的降解行为，首先制备三亚甲基碳酸脂与外消旋丙交酯的共聚物，再研究其降解过程中的性能变化。
先合成相同分子量不同组成比共聚物，再合成不同分子量相同组成比的共聚物。
再表征共聚物理化性能，然后表征聚合物降解过程中的理化性能。
2. 实验内容和要求
根据毕业要求指点4.2，本课题要开展的实验内容和要求如下：1． 三亚甲基碳酸酯与外消旋丙交酯共聚物的制备：我们将TMC和(L)LA，在引发剂辛酸亚锡 Sn(Oct)2的作用下，于高真空条件下使用本体聚合法制成无规共聚物。
2. 利用PBS磷酸盐缓冲溶液、脂肪酶溶液在恒温气浴振荡器中模拟人体生理环境以检测可降解碳酸酯基共聚物的体外降解行为。
3. 对所制备出的材料进行表征，要求学生能够熟练处理数据，并能够对表征结果的正确性与合理性进行分析与解释。
3. 参考文献
1. Albertsson, A.C. and M. Sjoling, Homopolymerization of 1,3-dioxan-2-one to high-molecular-weight poly(trimethylene carbonate). Journal of Macromolecular Science-Pure and Applied Chemistry, 1992. 29(1): 43-54.2. Yang, L., et al., The degradation of poly(trimethylene carbonate) implants: The role of molecular weight and enzymes. Polymer Degradation and Stability, 2015. 122: 77-87.3. Takahashi, Y. and R. Kojima, Crystal structure of poly(trimethylene carbonate). Macromolecules, 2003. 36(14): 5139-5143.4. Pego, A.P., D.W. Grijpma, and J. Feijen, Enhanced mechanical properties of 1,3-trimethylene carbonate polymers and networks. Polymer, 2003. 44(21): 6495-6504.5. Schuller-Ravoo, S., J. Feijen, and D.W. Grijpma, Flexible, elastic and tear-resistant networks prepared by photo-crosslinking poly(trimethylene carbonate) macromers. Acta Biomaterialia, 2012. 8(10): 3576-3585.6. Wang, F., et al., Synthesis, characterization and surface modification of low moduli poly(ether carbonate urethane)ureas for soft tissue engineering. Acta Biomaterialia, 2009. 5(8): 2901-2912.7. Loh, X.J., W. Guerin, and S.M. Guillaume, Sustained delivery of doxorubicin from thermogelling poly(PEG/PPG/PTMC urethane)s for effective eradication of cancer cells. Journal of Materials Chemistry, 2012. 22(39): 21249-21256.8. Woodruff, M.A. and D.W. Hutmacher, The return of a forgotten polymer-Polycaprolactone in the 21st century. Progress in Polymer Science, 2010. 35(10): 1217-1256.9. Ulery, B.D., L.S. Nair, and C.T. Laurencin, Biomedical Applications of Biodegradable Polymers. Journal of Polymer Science Part B-Polymer Physics, 2011. 49(12): 832-864.10. Chu, D., et al., Enzyme-responsive surface erosion of poly(ethylene carbonate) for controlled drug release. European Journal of Pharmaceutics and Biopharmaceutics, 2013. 85(3): 1232-1237.11. Zhu, K.J., et al., synthesis, properties, and biodegradation of poly(1,3-trimethylene carbonate). Macromolecules, 1991. 24(8): 1736-1740.12. Zhang, Z., et al., The in vivo and in vitro degradation behavior of poly(trimethylene carbonate). Biomaterials, 2006. 27(9): 1741-1748.13. Chen, B., et al., Using silk woven fabric as support for lipase immobilization: The effect of surface hydrophilicity/hydrophobicity on enzymatic activity and stability. Biomass 2021.1.5至2021.1.31毕业设计准备，准备开题报告及资料搜集。
2021.2.1至2021.2.28准备开题报告，明确研究方案。
2021.3.1至2021.3.31购买药品和搭建实验仪器，合成改性明胶。
