全文总字数：3232字
1. 毕业设计（论文）的内容和要求
课题简介对乙酰氨基酚是扑热息痛的化学成分，是一种酰胺类化合物，简称APAP。
它是一种常用的解热镇痛药物，与阿斯匹林相比，具有刺激性小，极少有过敏反应等优点。
此外，它还可用于药物扑炎痛的合成，以及作为有机合成中间体、照相用化学药品和过氧化氢的稳定剂等。
2. 实验内容和要求
实验内容：1. 脂肪酶CRL生物合成对乙酰氨基酚催化体系的建立2. 液相色谱及质谱分析催化产物3. 催化体系的优化实验要求：1. 熟练掌握无菌操作技术。
2. 能够独立完成脂肪酶CRL催化合成对乙酰氨基酚。
3. 对催化产物进行液相色谱分析，熟练掌握液相色谱使用方法。
3. 参考文献
1. Kovi K E，Wolf C. One－Pot Oxidative Esterification and Amidation of Aldehydes［J］. Chem. Eur. J. 2008, 14(21) :6302－6315.2. Kang B，Fu Z，Hong S H. Ｒuthenium－Catalyzed Ｒedox－Neutral and Single－Step Amide Synthesis from Alcohol and Nitrile with Complete Atom Economy［J］. J. Am. Chem. Soc. 2013， 135(32) :11704－11707.3. Kim M，Lee J，Lee H Y， et al. Significant Self－Acceleration Effects of Nitrile Additives in the Ｒhodium－Catalyzed Conversion of Aldoximes to Amides: A New Mechanistic Aspect［J］. Adv. Synth. Catal. 2009，351(13) :807－812.4. Brennfuhrer A， Neumann H， Beller M. Palladium － Catalyzed Carbonylation Ｒeactions of Aryl Halides and Ｒelated Compounds［J］. Angew. Chem. Int. Ed. 2009, 48(23):4114－4133.5. Valeur, E.; Bradley, M. Amide Bond Formation: Beyond the Myth of Coupling Reagents. Chem. Soc. Rev. 2009, 38, 606631.6. Carey, J. S.; Laffan, D.; Thomson, C.; Williams, M. T. Analysis of the Reactions Used For the Preparation of Drug Candidate Molecules. Org. Biomol. Chem. 2006, 4, 23372347.7. Constable D J C , Dunn P J , Hayler J D , et al. Key green chemistry research: a perspective from pharmaceutical manufacturers [J]. Green Chem. 2007, 9, 411420.8. Fred, van, Rantwijk, et al. Lipase-Catalyzed Synthesis of Carboxylic Amides: Nitrogen Nucleophiles as Acyl Acceptor[J]. Monatsh. Chem. 2000, 131, 549569.9. van Rantwijk, F.; Sheldon, R. A. Enantioselective Acylation of Chiral Amines Catalysed by Serine Hydrolases. Tetrahedron 2004, 60, 501519.10. Gotor-Fernandez, V.; Busto, E.; Gotor, V. Candida Antarctica Lipase B: An Ideal Biocatalyst for the Preparation of Nitrogenated Organic Compounds. Adv. Synth. Catal. 2006, 348, 797812.11. PuertasS, BrievaR, RebolledoF, etal. Lipase catalyzed aminolysis of ethyl propiolate and acrylic esters. Synthesis of chiral acryl amides[J].Tetrahedron, 1993:49(19):4007-4014.12. YI-FONG, WANG, KIRILL, et al. Cross-Linked Crystals of Subtilisin Versatile Catalysts for Organic Synthesis[J]. Annals of the New York Academy of Sciences, 1996.13. Badji? J D , Kadnikova E N , Kosti? N M . Enantioselective aminolysis of an alpha-chloroester catalyzed by Candida cylindracea lipase encapsulated in sol-gel silica glass[J]. Organic Letters, 2001, 3(13):2025.14. 蒋成君,袁吕力,袁黄俊.金属-酶协同催化动力学拆分反应研究进展[J].化工进展,2016,35(3):807-814.15. 王静, 王华丽, 臧恒昌. 对乙酰氨基酚合成方法的研究进展[J]. 食品与药品, 2010(09):354-356.
4. 毕业设计（论文）计划
1.2021.2-2021.3 文献检索，进行课题的前期调研2.2021.3-2021.4 脂肪酶CRL催化体系的建立3.2021.3-2021.4脂肪酶CRL生物合成对乙酰氨基酚3.2021.4-2021.5合成体系优化4.2021.5-2021.6 毕业论文的撰写
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