亲水性聚合物刷功能化的荧光纳米粒子用于靶向细胞成像任务书

 2021-10-21 05:10

1. 毕业设计(论文)的内容和要求

1.1课题介绍:许多癌症的发生和发展通常与特定细胞表面聚糖的过度表达有关,已知这种表达会影响癌细胞的生长,分裂和转移能力[1-5]。

细胞表面异常糖基化的发生是疾病状态的信号[6,7]。

特别是,改变的细胞表面糖基化模式与癌症表型高度相关[8,9]。

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2. 参考文献

[1] Dube, D. H.; Bertozzi, C. R. Glycans in Cancer and Inflammation-Potential for Therapeutics and Diagnostics. Nat. Rev. Drug. Discov. 2005, 4 (6), 477-488.[2] Li, Q.; Li, G.; Zhou, Y.; Zhang, X.; Sun, M.; Jiang, H.; Yu, G. Comprehensive n-glycome Profiling of Cells and Tissues for Breast Cancer Diagnosis. J. Proteome. Res. 2019, 18 (6), 2559-2570.[3] Li, X.; Wang, X.; Tan, Z.; Chen, S.; Guan, F. Role of Glycans in Cancer Cells Undergoing Epithelial-mesenchymal Transition. Front. Oncol. 2016, 6, 33.[4] Ozcan, S.; Barkauskas, D. A.; Ruhaak, L. R.; Torres, J.; Cooke, C. L.; An, H. J.; Hua, S.;Williams, C. C.; Dimapasoc, L. M.; Kim, J. H.; Camorlinga-Ponce M.; Rocke D. C. B.; Solnick J.V. L.; Serum Glycan Signatures of Gastric Cancer. Cancer Prev. Res. 2014, 7 (2), 226-235.[5] Pinho, S. S.; Reis, C. A. Glycosylation in Cancer: Mechanisms and Clinical Implications. Nat.Rev. Cancer. 2015, 15, 540.[6] Lau, K. S.; Dennis, J. W. N-Glycans in Cancer Progression. Glycobiology 2008, 18 (10), 750-760.[7] Yuan, K.; Listinsky, C. M.; Singh, R. K.; Listinsky, J. J.; Siegal, G. P. Cell Surface Associated Alpha-L-fucose Moieties Modulate Human Breast Cancer Neoplastic Progression. Patholo. Oncol. Res. 2008, 14 (2), 145-156.[8] Tao, X.; Wang, N.; Qin, W. Gut Microbiota and Hepatocellular Carcinoma. Gastrointestinal Tumors 2015, 2 (1), 33-40.[9] Marsico, G.; Russo, L.; Quondamatteo, F.; Pandit, A. Glycosylation and Integrin Regulation in Cancer. Trends in Cancer 2018, 4 (8), 537-552.

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