电荷翻转型的131I标记功能化聚乙烯亚胺包裹金纳米颗粒的构建及其体外成像应用任务书

 2021-10-21 05:10

1. 毕业设计（论文）的内容和要求

1．文献查阅掌握文献查阅的一般方法，学会使用计算机在中国期刊网，维普数据库，超星数字图书馆，Elsevier、NCBI电子期刊，Springer Link全文电子期刊，pubmed等检索资源上查阅关于碘-131以及聚乙烯亚胺包裹金纳米颗粒的相关文献。

2．文献阅读及综述阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

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2. 参考文献

1） Mizuhara, T., K. Saha, et al. (2015). "Acylsulfonamide-Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH." Angewandte Chemie-International Edition 54(22): 6567-6570.2） Wang, S., P. Huang, et al. (2016). "Stimuli-Responsive Programmed Specific Targeting in Nanomedicine." ACS Nano 10(3): 2991-2994.3） Wen, S., K. Li, et al. (2013). "Multifunctional dendrimer-entrapped gold nanoparticles for dual mode CT/MR imaging applications." Biomaterials 34(5): 1570-1580.4） Zhou, B., J. Yang, et al. (2016). "PEGylated polyethylenimine-entrapped gold nanoparticles modified with folic acid for targeted tumor CT imaging." Colloids and Surfaces B-Biointerfaces 140: 489-496.5） Zhu, J. Y., L. Z. Zhao, et al. (2015). "Radionuclide 131I-labeled multifunctional dendrimers for targeted SPECT imaging and radiotherapy of tumors." Nanoscale 7(43): 18169-18178.6） Cheng, Y. J., J. Y. Zhu, et al. (2016). "131I-labeled multifunctional dendrimers modified with BmK CT for targeted SPECT imaging and radiotherapy of gliomas." Nanomedicine 11(10): 1253-1266.7） Zhao, L. Z., J. Y. Zhu, et al. (2015). "Chlorotoxin-conjugated multifunctional dendrimers labeled with radionuclide 131I for single photon emission computed tomography imaging and radiotherapy of gliomas." ACS Appl. Mater. Interfaces 7(35): 19798-19808.8） Sun, N., Zhao L. Z., et al. (2019). "131I-labeled polyethylenimine-entrapped gold nanoparticles for targeted tumor SPECT/CT imaging and radionuclide therapy." International Journal of Nanomedicine, 14, 4367-4381.9） Zhao, L. Z., Li, Y. J., et al. (2019). "Chlorotoxin peptide-functionalized polyethylenimine-entrapped gold nanoparticles for glioma SPECT/CT imaging and radionuclide therapy." Journal of Nanobiotechnology, 17:30 https://doi.org/10.1186/s12951-019-0462-6.10） Xiong, Z. J., Wang, Y., et al. (2017). "Dendrimers meet zwitterions: development of a unique antifouling nanoplatform for enhanced blood pool, lymph node and tumor CT imaging." Nanoscale, 9, 12295-12301.

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