1. 毕业设计（论文）的内容和要求
1、毕业论文内容苯并吡喃类化合物因其具有广泛的生理和药理活性，受到了广大研究者的关注。
苯并吡喃类化合物通常以醛，活性亚甲基化合物和各种可烯醇化的C-H活化酸性化合物为底物通过级联反应获得。
通常，化学催化合成法存在一些问题，比如：使用昂贵或难以制备的催化剂，需要较高的反应温度，底物范围较窄，有时只能获得中等收率的目标产物等。
2. 参考文献
[1] B Sameem， M Saeedi， M Mahdavi, et al. Synthesis, Docking Study and Neuroprotective Effects of Some Novel Pyrano[3,2-C]Chromene Derivatives Bearing Morpholine/Phenylpiperazine Moiety[J]. Bioorganic ImidPman Magnetic Nanocatalyst under Ultrasonic Irradiation or Reflux Conditions[J]. RSC Advances. 2015, 5(34): 26625-26633.[8] M A Zolfigol， N Bahrami-Nejad， F Afsharnadery, et al. 1-Methylimidazolium Tricyanomethanide {[Hmim]C(Cn)3} as a Nano Structure and Reusable Molten Salt Catalyst for the Synthesis of Tetrahydrobenzo[B]Pyrans Via Tandem Knoevenagel-Michael Cyclocondensation and 3,4-Dihydropyrano[C]Chromene Derivatives[J]. Journal of Molecular Liquids. 2016, 221: 851-859.[9] M M Heravi， M Mirzaei， S Y S Beheshtiha, et al. H5BW12O40 as a Green and Efficient Homogeneous but Recyclable Catalyst in the Synthesis of 4H-Pyrans Via Multicomponent Reaction[J]. Applied Organometallic Chemistry. 2018, 32(9): e4479.[10] M E Sedaghat， M Rajabpour Booshehri， M R Nazarifar, et al. Surfactant Modified Bentonite (Ctmab-Bentonite) as a Solid Heterogeneous Catalyst for the Rapid Synthesis of 3,4-Dihydropyrano[C]Chromene Derivatives[J]. Applied Clay Science. 2014, 95: 55-59.[11] K Tabatabaeian， M A Zanjanchi， M Mamaghani, et al. Anchoring of Ruthenium onto Imine-Functionalized Zeolite Beta: An Efficient Route for the Synthesis of 4h-Benzo[B]Pyrans and Pyrano[C]Chromenes[J]. Canadian Journal of Chemistry. 2014, 92(11): 1086-1091.[12] Y Fu， B Fan， H Chen, et al. Promiscuous Enzyme-Catalyzed Cascade Reaction: Synthesis of Xanthone Derivatives[J]. Bioorganic chemistry. 2018, 80: 555-559.[13] J-C Xu， W-M Li， H Zheng, et al. One-Pot Synthesis of Tetrahydrochromene Derivatives Catalyzed by Lipase[J]. Tetrahedron. 2011, 67(49): 9582-9587.[14] R S Bhosale， C V Magar， K S Solanke, et al. Molecular Iodine: An Efficient Catalyst for the Synthesis of Tetrahydrobenzo[B]Pyrans[J]. Synthetic Communications. 2007, 37(24): 4353-4357[15]胡燚,丁雁,黄和等.水相中脂肪酶Lipase lipoprotein 催化的Aldol 缩合反应[J].高校化学工程学报,2016,30(1)：121-126.
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