1. 毕业设计（论文）的内容和要求
1．文献查阅要求掌握文献查阅技能，学会运用网络资源如中国期刊网、维普数据库、Elsevier电子期刊、Web of Science科学引文索引、Pubmed数据库等检索资源,查阅关于竹节香附素A、结肠癌以及实验涉及内容相关文献。
2．文献阅读及综述阅读与课题相关的外文与中文文献，了解国内外的研究动态，撰写文献综述。
3．明确实验任务，拟定实验方案根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。
2. 参考文献
[1] Goncalves, G.D., Semprebon, S.C., Biazi, B.I., Mantovani, M.S., Fernandes, G.S.A., 2018.Bisphenol a reduces testosterone production in TM3 Leydig cells independently of its effects on cell death and mitochondrial membrane potential. Reprod. Toxicol. 76,2634.[2] Hao, L., Sun, Q., Zhong, W., Zhang, W., Sun, X., Zhou, Z., 2018. Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: a molecular mechanism of protection against alcoholic liver disease. Redox Biol. 14, 626636.[3] Haun, F., Nakamura, T., Lipton, S.A., 2013. Dysfunctional mitochondrial dynamics in the pathophysiology of neurodegenerative diseases. J. Cell Death 6, 2735.[4] Hu, J., Yu, Q.W., Zhao, F., Ji, J.Z., Jiang, Z.Z., Chen, X., Gao, P., Ren, Y.R., Shao, S.,Zhang, L.Y., Yan, M., 2015. Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells. Chem. Biol. Interact. 240, 3846.[5] Hu, Q., Ren, J., Li, G., Wu, J., Wu, X., Wang, G., Gu, G., Ren, H., Hong, Z., Li, J., 2018. The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway. Cell Death Dis. 9, 403.[6] Huang, D.H., Zhang, S.W., Zhao, H., Zhang, L., 2011. The role of C-type natriuretic peptide in rat testes during spermatogenesis. Asian J. Androl. 13, 275280.[7] Jeddi, F., Soozangar, N., Sadeghi, M.R., Somi, M.H., Samadi, N., 2017. Contradictory roles of Nrf2/Keap1 signaling pathway in cancer prevention/promotion and chemoresistance.DNA Repair 54, 1321.[8] Jiang, M., Kauppila, T.E.S., Motori, E., Li, X.P., Atanassov, I., Folz-Donahue, K., Bonekamp, N.A., Albarran-Gutierrez, S., Stewart, J.B., Larsson, N.G.R., 2017.[9] Increased Total mtDNA copy number cures male infertility despite unaltered mtDNA mutation load. Cell Metab. 26, 429.[10] Johnsen, S.G., 1970. Testicular biopsy score counta method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1, 225.[11] Jones, D.P., 2002. Redox potential of GSH/GSSG couple: assay and biological significance. Methods Enzymol. 348, 93112.[12] Kim, B., Song, Y.S., 2016. Mitochondrial dynamics altered by oxidative stress in cancer. Free Radic. Res. 50, 10651070.[13] Ko, E.Y., Sabanegh Jr., E.S., Agarwal, A., 2014. Male infertility testing: reactive oxygen species and antioxidant capacity. Fertil. Steril. 102, 15181527.[14] Kobayashi, M., Yamamoto, M., 2006. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv. Enzym. Regul. 46,113140.[15] Li, Z., Liu, X., Wang, L., Wang, Y., Du, C., Xu, S.Y., Zhang, Y.C., Wang, C.H., Yang, C.F.,2016. The role of PGC-1 alpha and MRP1 in lead-induced mitochondrial toxicity intesticular Sertoli cells. Toxicology 355, 3948.[16] Liu, B., Wu, S.D., Shen, L.J., Zhao, T.X., Wei, Y., Tang, X.L., Long, C.L., Zhou, Y., He, D.W.,Lin, T., Wei, G.H., 2019. Spermatogenesis dysfunction induced by PM2.5 from automobileexhaust via the ROS-mediated MAPK signaling pathway. Ecotoxicol.Environ. Saf. 167, 161168.[17] Ma, B., Li, X.T., Li, J., Zhang, Q., Liu, Y.H., Yang, X.J., Sun, J.J., Yao, D., Liu, L., Liu, X.X.,Ying, H.J., 2014. Quantitative analysis of tenuifolin concentrations in rat plasma and tissue using LC-MS/MS: application to pharmacokinetic and tissue distribution study.J. Pharmaceut. Biomed. 88, 191200.[18] Ma, B., Qi, H.H., Li, J., Xu, H., Chi, B., Zhu, J.W., Yu, L.S., An, G.H., Zhang, Q., 2015.Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: a GC-MS based metabolomics study. Toxicology 336, 8495.[19] Miquel, E., Cassina, A., Martinez-Palma, L., Souza, J.M., Bolatto, C., Rodriguez-Bottero, S., Logan, A., Smith, R.A., Murphy, M.P., Barbeito, L., Radi, R., Cassina, P., 2014.Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model ofinherited amyotrophic lateral sclerosis. Free Radic. Biol. Med. 70, 204213.[20] Nguyen, T., Nioi, P., Pickett, C.B., 2009. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J. Biol. Chem. 284, 1329113295.[21] Perez-Ternero, C., Werner, C.M., Nickel, A.G., Herrera, M.D., Motilva, M.J., Bohm, M., Alvarez de Sotomayor, M., Laufs, U., 2017. Ferulic acid, a bioactive component of rice bran, improves oxidative stress and mitochondrial biogenesis and dynamics inmice and in human mononuclear cells. J. Nutr. Biochem. 48, 5161.[22] Porteous, C.M., Menon, D.K., Aigbirhio, F.I., Smith, R.A., Murphy, M.P., 2013. P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain. Biochim. Biophys. Acta 1830, 34583465
以上是毕业论文任务书，课题毕业论文、开题报告、外文翻译、程序设计、图纸设计等资料可联系客服协助查找。
