1. 毕业设计（论文）的内容和要求
一、 论文内容： 几丁寡糖是几丁质降解的重要产物，因具有抗癌、消炎、抗氧化、降血脂及提高免疫力等重要药理学性质，被广泛用作于各类名贵药品的开发。
传统制备几丁寡糖的方法存在环境污染严重、对海洋甲壳资源依赖大、产物聚合度不可控和质量不稳定等问题，工业生产面临瓶颈。
目前利用微生物发酵法已实现了N-乙酰氨基葡萄糖的大规模工业化制备，但以其直接作为原料合成氨基寡糖的相关技术研究还较少。
2. 参考文献
[1] 刘星. 几丁寡糖联合顺铂对肺癌A549细胞及其移植瘤的影响[D].[2] Xia G Q, Jin C S, Zhou J, et al. A novel chitinase having a unique mode of action from A sergillus fumigatus YJ-407 [J].Eur. J. Biochem., 2001268 (14):4079-4085.[3] Zhang H, Du Y G, Yu X J, et al. Preparation of chitooligosaccharides from chitosan by a complex enzyme [J]. Carbohyd. Res., 1999, 320(3-4): 257-260.[4] Suzuki K, Okawa Y, Hashimoto K, et al. Protecting effect of chitin and chitosan on experimentally induced rnurine candidiasis [J]. Microbiol. Immunol., 2013,28(8):903-912.[5]王明，叶新山.糖链的化学合成[J].生命科学，2011, 23(6): 592-597.[6] Dai N N, et al. Production of chitin oligosaccharides with different molecular weights and their antioxidant effect in RAW 264.7 cells[J]. J. Funct. Foods, 2009.[7] Li, X D, Zhao, et al. Chitobiose alleviates oleic acid-induced lipid accumulation by decreasing fatty acid uptake and triglyceride synthesis in HepG2 cells[J]. J. Funct. Foods, 2018.[8] Yang Q, Jin Y X, Hao H Z, et al. Chitin oligosaccharide (COS) reduces antibiotics dose and prevents antibiotics-caused side effects in adolescent idiopathic scoliosis (AIS) patients with spinal fusion surgery[J]. Marine Drugs, 2017, 15(3):70-.[9] 刘美思. 几种海洋寡糖免疫调控作用初探[D][10] Chang K L B, Tai M C, Cheng F H. Kinetics and products of the degradation of chitosan by hydrogen peroxide[J]. J. Agri. Food Chem., 2001, 49(10):4845-4851.[11] Qin Z, Chen Q, Lin S, et al. Expression and characterization of a novel cold adapted chitosanase suitable for chitooligosaccharides controllable preparation[J]. Food Chem., 2018, 253.[12] Rao V P, Krishna M M, Narayan D S, et al. Applicability of endochitinase of, Flavobacterium johnsoniae, with transglycosylation activity in generating long-chain chitooligosaccharides[J]. Int. J. Biol. Macromolecules, 2018, 117:62-71.[13] Zhang A, Wei G, Mo X, et al. Enzymatic hydrolysis of chitin pretreated by bacterial fermentation to obtain pure N-acetyl-D-glucosamine[J]. Green Chem., 2018:10.1039.
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