1. 毕业设计（论文）的内容、要求、设计方案、规划等
1、前言 前言要对羟基酪醇的来源、分离纯化、活性功能做简要说明；阐述近年来国内外羟基酪醇的方法、研究现状，同时介绍本论文的目的意义。
2.方案拟定本课题在羟基酪醇分子中引入亲脂性长链脂肪酸或有机酸，改变其亲水/疏水平衡，提高其生理活性。
得到的衍生物产物将采用红外、质谱和核磁共振等方法进一步表征结构。
2. 参考文献（不低于12篇）
1 延永，郭媛，彭梦姣，安静，恩达. 羟基酪醇的合成. 精细化工,2012(10),29(10)：985-988.2刘威振, 张兴, 陈新建, 等. 羟基酪醇药理作用研究进展[J]. 广东药学院学报, 2012, 28(6): 684688. 3叶建中，王成章，陈红霞，董艳鹤. 油橄榄叶中羟基酪醇含量及提取工艺研究. 林产化学与工业， 2011,31（1）：63-67.4王晓飞，李辰，郑媛媛，邸多隆. 油橄榄叶多酚类成分研究. 中草药，2011,42（5）：848-851.5 PEREIRA-CARO G, MADRONA A, BRAVO L, et al. Antioxidant activity evaluation of alkyl hydroxytyrosyl ethers, a new class of hydroxytyrosol derivatives[J]. Food Chemistry, 2009, 115(1): 8691. 6 MADRONA A, PEREIRA-CARO G, MATEOS R, et al. Synthesis of hydroxytyrosyl alkyl ethers from olive oil waste waters[J]. Molecules, 2009, 14(5): 17621772. 7 延永, 郭媛, 彭梦姣, 等. 羟基酪醇的合成[J]. 精细化工, 2012, 29(10): 985988. 8 许超, 高俊超, 张坚, 等. 羟基酪醇合成工艺研究[J]. 精细化工, 2012, 27(12): 12091212. 9 PEREIRA-CARO G, SARRIA B, MADRONA A, et al. Alkyl hydroxytyrosyl ethers show protective effects against oxidative stress in HepG2 cells[J]. Journal of Agricultural and Food Chemistry, 2011, 59(11): 59645976. 10 PEREIRA-CARO G, MATEOS R, TRAKA M H, et al. Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol[J]. Food Chemistry, 2013, 138(2/3): 11721182. 11MATEOS R, PEREIRA-CARO G, BACON J R, et al. Anticancer Activity of Olive Oil Hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells[J]. Journal of Agricultural and Food Chemistry, 2013, 61(13): 32643269. 12 PROCOPIO A, CELIA C, NARDI M, et al. Lipophilic hydroxytyrosol esters: Fatty acid conjugates for potential topical administration[J]. Journal of Natural Products, 2011, 74(11): 23772381. 13 BOUALLAGUI Z, BOUAZIZ M, LASSOUED S, et al. Hydroxytyrosol acyl esters: Biosynthesis and activities[J]. Applied Biochemistry and Biotechnology, 2011, 163(5): 592599. 14 BERNINI R, MINCIONE E, BARONTINI M, et al. Convenient synthesis of hydroxytyrosol and its lipophilic derivatives from tyrosol or homovanillyl alcohol[J]. Journal of Agricultural and Food Chemistry, 2008, 56(19): 88978904.15 BERNINI R, CRISANTE F, BARONTINI M, et al. Synthesis and structure/antioxidant activity relationship of novel catecholic antioxidant structural analogues to hydroxytyrosol and its lipophilic esters[J]. Journal of Agricultural and Food Chemistry, 2012, 60(30): 74087416.16 REZAEI-SADABADY R, ZARGHAMI N, BARZEGAR A, et al. Studies of the relationship between structure and antioxidant activity in interesting systems, including tyrosol, hydroxytyrosol derivatives indicated by quantum chemical calculations[J]. Soft, 2013, 2(3): 1318. 17 TRINCONE A, PAGNOTTA E, TRAMICE A. Enzymatic routes for the production of mono- and di-glucosylated derivatives of hydroxytyrosol[J]. Bioresource Technology, 2012, 115: 7983.
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